During our research work, we managed to produce ZIF-8 in several series of experiments using various non-linear chemical systems (autocatalytic and enzymatic clock-type reactions, autonomous and non-autonomous pH-oscillations). Based on the results obtained, the time-varying pH environment has an influence on the morphology and average particle size of the framework structures. We are able to create non-autonomous pH-oscillating acid-base systems by adding acidic and alkali solutions at a time-varying rate, which can show oscillatory activity in a wider pH range, thus opening up the possibilities for the examination of various extremely pH-sensitive substances such as gold nanoparticles and oleic acid micelles.